Some immunity to novel H1N1 flu found in seniors

Posted On Nov 18 2020 by

first_imgMay 21, 2009 (CIDRAP News) – In a search for factors that may give some patients a protective edge against novel H1N1 influenza, researchers said today that adults, especially those older than 60, appear to have some cross-antibody response but that seasonal influenza vaccines appear unlikely to offer any protection.The findings, from scientists at the US Centers for Disease Control and Prevention (CDC) appear in tomorrow’s edition of Morbidity and Mortality Weekly Report (MMWR). Results are based on microneutralization and hemagglutination inhibition assays on child and adult serum specimens that were used in previous vaccine studies by the CDC as well as its academic and industry partners.Epidemiologic patterns in the novel flu outbreak have consistently shown the disease taking its hardest toll on younger people—in the United States, 64% of the novel flu cases have occurred in the 5- to 24-year-old age-group. Officials have wondered if older people haven’t yet been exposed to the strain in the community or if another factor, such as preexisting immunity, is providing some protection against the virus. Only 1% of cases have occurred in people over age 65.Researchers assessed cross-reactive antibody levels to the novel influenza H1N1 virus in cohorts of children and adults before and after they had been vaccinated with a seasonal flu vaccine during any of the past four seasons.Before vaccination, children showed no cross-reactive antibody reaction to the new flu strain. However, the antibody was detected in 6% to 9% of adults ages 18 to 64 and in 33% of those older than age 60.Vaccination with any form of the seasonal flu vaccine did not provoke a response to the novel strain in children. Adults ages 18 to 64 who had been vaccinated showed a slight response to the new strain: a twofold increase compared with 12-fold to 19-fold increases seen against the seasonal H1N1 strain. No increase in cross-reactive antibody response was seen in people over age 60 who had been vaccinated.”These data suggest that receipt of recent (2005-2009) seasonal influenza vaccines is unlikely to elicit a protective antibody response to the novel influenza A (H1N1) virus,” the CDC reported.Though the number of sera samples from children was small, the findings suggest that US children are serologically naive to the new virus, the researchers concluded. However, the analysis suggests adults—especially those older than 60—have some degree of preexisting immunity to the novel strain.Anne Schuchat, MD, interim deputy director for the CDC’s science and public health program, today at a media briefing urged caution in interpreting the results. Cross-reactive antibody assessment is an indirect measure of immune response, and though the findings are interesting, they’re not definitive, she said. “The laboratory findings we’re reporting seem to correlate with the epidemiologic data that we have so far.”Another reason to not over-interpret the results, she said, is that the microneutralization assay was used as a surrogate and isn’t the standard test the CDC uses against influenza viruses. (Microneutralization assays appear more sensitive, but researchers have not agreed on clinical correlates for the method.) She also said the study findings are based on relatively small numbers of patient serum samples.The response in older people could be explained by exposure to a related virus, exposure to a seasonal flu vaccine that provided protection, or that immune response to the new virus might be similar to that of other viruses, Schuchat said. However, she added that CDC virologists have compared the novel strain with past viruses and found that the new one is very different. “It’s not a close genetic match,” she said.She also said experts aren’t very impressed by the prevaccination-to-postvaccination ratio of 2:1 that suggests a weak response to the new virus. “That’s pretty wimpy,” Schuchat said, adding that the ratio for seasonal flu vaccines ranges around 12:1. “Wouldn’t it be great if there was boosting? But we don’t think we have sufficient evidence of that at this point,” she said.CDC. Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR 2009 May 22;58(19):521-4 [Full text]See also:May 6 CIDRAP News story “Fewer senior swine flu cases may hint at protection”last_img read more


DWOMOH: Dede to Swans a sensible downgrade on Marseille

Posted On Aug 28 2020 by

first_imgSwansea?Why?What happened to all the other links to the player that we had been hearing the last fortnight?These were but a few questions posed when the news of André ‘Dede’ Ayew signing for the Welsh team came through.His viewHear him after his signing for the Swans: “I am very happy to sign for Swansea which is a very good club in the Premiership. I spent so many years in the Youth team at Marseille before moving to the first team. It was a difficult moment for me to leave [Olympique Marseille] and make a decision but with time and growing up, I thought maybe it was time to go where I dreamt and always wanted to play.” “It was time for me to move on. Honestly, it is true that I had a lot of offers and stuffs so I needed to take my time and make the right decision for my future. I don’t want to jump the steps. I want to take it step by step.””For me, with the desire to play in the Premiership and wanting to grow as a player and to become a better player, I think that Swansea was the best solution for me in every way and the project that the club has for the future. When I spoke to [Swansea] coach [Garry Monk] and the chairman [Huw Jenkins], I felt that this was the right way for me to go.”Sounds logical from a player of Andrés stature: big game player with a big game experience, widely travelled and a proven winner.He definitely knows what he’s talking about.  He has not been a one club man though, despite being on the books of Marseille since 2005. Not to take anything away from the lad, but Abedi Ayew Snr’s connections with the club where he was instrumental in their Champion’s League win in 1993 meant Dede’s transition to the south of France from FC Nania was going to be smooth.But still, it had to take blood, sweat and tears for the young man to make the grade at the Velodrome. Loan moves to Lorient and Arles Avignon was only to toughen him up and make him a better player.Sterling performances at the FIFA U-20 World Cup in Egypt, where he skippered Ghana to gold in 2009, coupled with a very good showing with the senior at the 2010 Afcon sent him on his way.The World Cup in South Africa later that year simply enhanced his reputation, and he’s only become better in the last five years.England’s lure too strong But in the face of his acceleration in the sport, there was a challenge.The lure of playing in the Premiership was playing on his mind.He had been in France for ten years and won a decent number of silverware: two League Cups in 2011 and 2012, two Trophées des Champions (Super Cups) in 2010 and 2011. And to top that, he was playing for the biggest club in France at a venue where average attendances exceeded 50,000. But somehow, this big club that gave him regular playing time was not enough. Dede needed European football and even more wages. Upgrade or downgrade?He allowed his contract to run down under Marcelo Bielsa and has now opted to sign for a club that was only good enough for eighth in the Premier league. And Swansea is a side who only joined the elite of English football only four years ago.He would play in front of 20,759 fans at the Liberty Stadium when it’s full in South Wales and his mates would be “stars” like Welsh skipper Ashley Williams, Bafetembi Gomis, Jonjo Shelvey, Ki Sung Yueng and Nathan Dyer.Not good enough quality by any imagination.At last season’s Swansea end of season awards, Jenkins spoke at length about improving the squad with quality players to challenge for honors. But the reality is that one only has to look at the gulf in class between the top six and you’ve to say that their biggest chances of winning laurels can only be in cup competitions, like they did with the Capital One Cup two years ago.Swansea do not play the most exciting brand of football and it would take something special from the deputy Ghanaian skipper to push them beyond eighth next season.It’s been said that the quality around you often pushes individuals to new heights in their field of work, but I’m not too sure about that at Swansea.Look at Wilfred Bony, who was smart enough to jump ship when City came calling. He was going to a club where there was that opportunity to further develop, earn huge wages, play alongside some of the biggest names in the sport and win trophies. That’s what it is for people of ambition. And I refuse to be convinced that Ayew would be at the Liberty Stadium all four years of his contract. He would not kid anyone with that kind of talk.Dede has always craved a top Premiership club, and it’s only seasons away, I reckon. At 25, he’s in his prime and could even be around at the high level for another six to seven seasons.It makes this decision even more intriguing one.Going forwardThe jury would definitely be on the lookout when he makes his competitive debut for the Swans in August. Meantime, the popularity of Dede’s move means should Jenkins would be smart enough, he could make a healthy return on investment if Swansea open a club shop in Accra!André Ayew, the son of the maestro, we’d be cheering you on. Make us proud in the Swans kit and don’t hesitate to jump ship when the big boys come calling.You don’t need to tell us that is what you really want.  We know.‏–Kwame Dwomoh-Agyemang is a Joy Sports producer. Follow him on Twitter: @DwomohKwamelast_img read more