May 21, 2009 (CIDRAP News) – In a search for factors that may give some patients a protective edge against novel H1N1 influenza, researchers said today that adults, especially those older than 60, appear to have some cross-antibody response but that seasonal influenza vaccines appear unlikely to offer any protection.The findings, from scientists at the US Centers for Disease Control and Prevention (CDC) appear in tomorrow’s edition of Morbidity and Mortality Weekly Report (MMWR). Results are based on microneutralization and hemagglutination inhibition assays on child and adult serum specimens that were used in previous vaccine studies by the CDC as well as its academic and industry partners.Epidemiologic patterns in the novel flu outbreak have consistently shown the disease taking its hardest toll on younger people—in the United States, 64% of the novel flu cases have occurred in the 5- to 24-year-old age-group. Officials have wondered if older people haven’t yet been exposed to the strain in the community or if another factor, such as preexisting immunity, is providing some protection against the virus. Only 1% of cases have occurred in people over age 65.Researchers assessed cross-reactive antibody levels to the novel influenza H1N1 virus in cohorts of children and adults before and after they had been vaccinated with a seasonal flu vaccine during any of the past four seasons.Before vaccination, children showed no cross-reactive antibody reaction to the new flu strain. However, the antibody was detected in 6% to 9% of adults ages 18 to 64 and in 33% of those older than age 60.Vaccination with any form of the seasonal flu vaccine did not provoke a response to the novel strain in children. Adults ages 18 to 64 who had been vaccinated showed a slight response to the new strain: a twofold increase compared with 12-fold to 19-fold increases seen against the seasonal H1N1 strain. No increase in cross-reactive antibody response was seen in people over age 60 who had been vaccinated.”These data suggest that receipt of recent (2005-2009) seasonal influenza vaccines is unlikely to elicit a protective antibody response to the novel influenza A (H1N1) virus,” the CDC reported.Though the number of sera samples from children was small, the findings suggest that US children are serologically naive to the new virus, the researchers concluded. However, the analysis suggests adults—especially those older than 60—have some degree of preexisting immunity to the novel strain.Anne Schuchat, MD, interim deputy director for the CDC’s science and public health program, today at a media briefing urged caution in interpreting the results. Cross-reactive antibody assessment is an indirect measure of immune response, and though the findings are interesting, they’re not definitive, she said. “The laboratory findings we’re reporting seem to correlate with the epidemiologic data that we have so far.”Another reason to not over-interpret the results, she said, is that the microneutralization assay was used as a surrogate and isn’t the standard test the CDC uses against influenza viruses. (Microneutralization assays appear more sensitive, but researchers have not agreed on clinical correlates for the method.) She also said the study findings are based on relatively small numbers of patient serum samples.The response in older people could be explained by exposure to a related virus, exposure to a seasonal flu vaccine that provided protection, or that immune response to the new virus might be similar to that of other viruses, Schuchat said. However, she added that CDC virologists have compared the novel strain with past viruses and found that the new one is very different. “It’s not a close genetic match,” she said.She also said experts aren’t very impressed by the prevaccination-to-postvaccination ratio of 2:1 that suggests a weak response to the new virus. “That’s pretty wimpy,” Schuchat said, adding that the ratio for seasonal flu vaccines ranges around 12:1. “Wouldn’t it be great if there was boosting? But we don’t think we have sufficient evidence of that at this point,” she said.CDC. Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR 2009 May 22;58(19):521-4 [Full text]See also:May 6 CIDRAP News story “Fewer senior swine flu cases may hint at protection”
Mrs. Helen Louise (Swearingen) Graham, age 89, of Vevay, Indiana, entered this life on April 13, 1928, in Adams County, Ohio, the daughter of the late, Christian and Ella Grace (Ayers) Swearingen. She was raised in Decatur, Ohio and was a 1946 graduate of the West Union High School in West Union, Ohio. Helen was united in marriage on June 21, 1952, in Cincinnati, Ohio, to the late, Nelson Lindsay “Red” Graham and to this union arrived three children to bless their home. Helen and Red shared 56 years of marriage together until Red passed away on December 16, 2008. In her early years of life, Helen was employed for Cole Bakes Insurance in Vevay, Indiana. Helen was later employed for Seagram’s Distillery in Lawrenceburg, Indiana, retiring in 1993, after 37 years of service. She was a member of the Ruter Chapel United Methodist Church in Vevay, Indiana and the Vevay American Legion Post !85 Ladies Auxiliary. Helen enjoyed sewing, working crossword puzzles, socializing with her family and friends and having a glass of wine overlooking the Ohio River. Helen passed away at 4:00 am, Friday, June 16, 2017, at the Swiss Villa Nursing & Rehabilitation Center in Vevay, Indiana.Helen will be dearly missed by her daughter, Christi Dixon and her husband: David of Henderson, KY; her son, Mark Graham and his wife: Deanna of Vevay, IN; her grandchildren, Jesse Dixon and his wife: Kate, Neil Dixon and his wife: Meredith, Nathan Graham, and his wife: Taylor Natalie Dickerson and her husband: Josh, Evan Graham; her great-grandchildren, Tessa Dixon, Arya Dickerson and Nora Dixon; her brother, Dale Swearingen of Medina, OH; her sister, Sandy Ditmer of Hillsboro, OH; her sister-in-law, Jean Adkins of Versailles, IN and her several nieces and nephews.She was preceded in death by her parents, Christian and Ella Grace (Ayers) Swearingen; her husband, Nelson Lindsay “Red” Graham, died December 16, 2008; her son, Brett Lee Graham, died February 16, 2008 and her sister, Bobbie Holiday.Funeral services will be conducted Sunday, June 25, 2017, at 1:00 pm, by Rev. Mike Jones at the Haskell & Morrison Funeral Home, 208 Ferry Street Vevay, Indiana 47043. Interment will follow in the Vevay Cemetery, Vevay, Indiana.Friends may call 11:00 am – 1:00 pm, Sunday, June 25, 2017, at the Haskell & Morrison Funeral Home 208 Ferry Street Vevay, Indiana 47043. Memorial contributions may be made to Community Foundation of Switzerland County. Cards are available at the funeral home.
Now, Nigel Pearson’s side sit three places and three points above the drop zone and can clinch their place in the top flight for another season with victory at relegation rivals Sunderland next Saturday – should other results also go their way. Pearson insists spirit has never been a problem in his camp and is at a loss to explain the recent upturn in results. “It has been a big factor in our change of fortune, but throughout the season it’s been a big factor,” said the Leicester boss, who this week was named manager of the month for April. “From my own perspective of being in the dressing room, we’ve never lost hope of what we can achieve. “It’s been tough because when you look at the run we’re on currently, which is pretty unthinkable really in the context of our season, we’ve needed to when you look at the results of the other teams who are down there with us. “We’ve not been able to pull away and that might have had a negative affect, but it hasn’t. And that is testament to our players. “We need to keep showing it in the two remaining matches as they are against teams down there with us, battling against us. Against teams who also need the points. “I don’t know why it has changed for us. I don’t know what the difference has been. We’ve played well for a long time but now we’re keeping clean sheets and scoring more. It sound basic but it’s hard to give a definitive answer. Leicester’s team spirit was hailed by both managers after the Foxes continued their march towards Barclays Premier League survival against Southampton at the King Power Stadium. “Our managing of the game during games has improved. That has come with the experience of playing in the Premier League. We didn’t have that at the beginning of the season. “But the margins are so small between a good performance that yields no points and a good performance that wins three points. I can think of a number of occasions this season when we’ve played exceptionally well and come away with nothing.” Leicester travel to Sunderland next before finishing the season at home to QPR, who will be relegated on Sunday if they fail to win at Manchester City. Pearson added: ” We’re in a decent position now but we won’t be getting ahead of ourselves. We will be making sure our application is right in those games too. “If two months ago you’d have said it would be in our own hands going into the last game of the season, I’d have taken it.” Riyad Mahrez enhanced his growing reputation by scoring both goals for Leicester with the only down side for the Foxes a serious-looking injury sustained by Matty James. Southampton have entertained for much of the season and earned plaudits for mounting a challenge for the European places but they disappointed on Saturday. A fourth straight away loss looks to have finally ended their hopes of catching Liverpool in fifth spot. Ronald Koeman was impressed by Leicester spirit but also admitted his side were off the pace. “We knew what Leicester did last week, scoring an early goal, but we had problems at the beginning,” said the Saints boss. “There was a lack of sharpness, which was strange after last week. “Leicester started confidently and were aggressive. They had two chances and scored two goals. That makes it difficult and that is why we lost today – no sharpness at the start of the game. “We didn’t create a lot. We changed things in the second half a bit but it was difficult – good organisation and positioning from Leicester. “Leicester we’re full of confidence and had a cause. They were fighting for something. Fighting against relegation. Fighting for their lives. “We didn’t have that in our play, there was too much doubting in our side.” The 2-0 win, a sixth success in seven matches, is the latest in what has been a remarkable turnaround in fortune for Leicester. A month ago they looked dead and buried and set for a return to the Sky Bet Championship after a eight-game winless run which included six defeats. Press Association