May 21, 2009 (CIDRAP News) – In a search for factors that may give some patients a protective edge against novel H1N1 influenza, researchers said today that adults, especially those older than 60, appear to have some cross-antibody response but that seasonal influenza vaccines appear unlikely to offer any protection.The findings, from scientists at the US Centers for Disease Control and Prevention (CDC) appear in tomorrow’s edition of Morbidity and Mortality Weekly Report (MMWR). Results are based on microneutralization and hemagglutination inhibition assays on child and adult serum specimens that were used in previous vaccine studies by the CDC as well as its academic and industry partners.Epidemiologic patterns in the novel flu outbreak have consistently shown the disease taking its hardest toll on younger people—in the United States, 64% of the novel flu cases have occurred in the 5- to 24-year-old age-group. Officials have wondered if older people haven’t yet been exposed to the strain in the community or if another factor, such as preexisting immunity, is providing some protection against the virus. Only 1% of cases have occurred in people over age 65.Researchers assessed cross-reactive antibody levels to the novel influenza H1N1 virus in cohorts of children and adults before and after they had been vaccinated with a seasonal flu vaccine during any of the past four seasons.Before vaccination, children showed no cross-reactive antibody reaction to the new flu strain. However, the antibody was detected in 6% to 9% of adults ages 18 to 64 and in 33% of those older than age 60.Vaccination with any form of the seasonal flu vaccine did not provoke a response to the novel strain in children. Adults ages 18 to 64 who had been vaccinated showed a slight response to the new strain: a twofold increase compared with 12-fold to 19-fold increases seen against the seasonal H1N1 strain. No increase in cross-reactive antibody response was seen in people over age 60 who had been vaccinated.”These data suggest that receipt of recent (2005-2009) seasonal influenza vaccines is unlikely to elicit a protective antibody response to the novel influenza A (H1N1) virus,” the CDC reported.Though the number of sera samples from children was small, the findings suggest that US children are serologically naive to the new virus, the researchers concluded. However, the analysis suggests adults—especially those older than 60—have some degree of preexisting immunity to the novel strain.Anne Schuchat, MD, interim deputy director for the CDC’s science and public health program, today at a media briefing urged caution in interpreting the results. Cross-reactive antibody assessment is an indirect measure of immune response, and though the findings are interesting, they’re not definitive, she said. “The laboratory findings we’re reporting seem to correlate with the epidemiologic data that we have so far.”Another reason to not over-interpret the results, she said, is that the microneutralization assay was used as a surrogate and isn’t the standard test the CDC uses against influenza viruses. (Microneutralization assays appear more sensitive, but researchers have not agreed on clinical correlates for the method.) She also said the study findings are based on relatively small numbers of patient serum samples.The response in older people could be explained by exposure to a related virus, exposure to a seasonal flu vaccine that provided protection, or that immune response to the new virus might be similar to that of other viruses, Schuchat said. However, she added that CDC virologists have compared the novel strain with past viruses and found that the new one is very different. “It’s not a close genetic match,” she said.She also said experts aren’t very impressed by the prevaccination-to-postvaccination ratio of 2:1 that suggests a weak response to the new virus. “That’s pretty wimpy,” Schuchat said, adding that the ratio for seasonal flu vaccines ranges around 12:1. “Wouldn’t it be great if there was boosting? But we don’t think we have sufficient evidence of that at this point,” she said.CDC. Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR 2009 May 22;58(19):521-4 [Full text]See also:May 6 CIDRAP News story “Fewer senior swine flu cases may hint at protection”
The weekend all high school basketball fans have been waiting for is here! The sectionals move into the semi-final rounds tonight. Go out and root for your favorite team. It is the best entertainment in town. Here are the area teams.In 4A East Central will be playing Bloomington South at Columbus East the first game.In 3A Batesville is battling Greensburg in the first game of the Greensburg sectional, while Lawrenceburg will battle Franklin County.In 2A Switzerland County takes on North Decatur, and South Decatur plays Southwestern of Hanover on their home court.In 1A Oldenburg Academy plays Jac-Cen-Del, and Hauser takes on Morristown at Southwestern of Shelby.According to the experts, the 4 teams expected to win are: Bloomington South, Greensburg, Southwestern of Hanover, and Morristown. I wouldn’t bet the house that all of 4 of these will be the champions.
MAN CITY VS SUNDERLANDMAN CITY (4-2-3-1)HART, SAGNA, DEMICHELIS, OTAMENDI, KOLAROV, FERNANDINHO, FERNANDO, DE BRUYNE, SILVA, STERLING, AGUEROSUNDERLAND (5-3-2)DEFOE, WATMORE, JOHNSON, M’VILA, TOIVONEN, VAN AANHOLT, KABOUL, O’SHEA, COATES, JONES, PANTILIMONOn Monday, Manchester City lost 2-1 to Barclays Premier League rivals Arsenal at the Emirates Stadium, leaving them in third place and six points behind leaders Leicester City.It further highlighted City’s problems away from home.; of their 33 goals in the Premier League this season, no fewer than 25 have come at the Etihad Stadium.Sunderland, meanwhile, have lost their last three and five of their last seven, results that leave the Black Cats in the relegation zone, in 19th place. And they arrive at the Etihad Stadium where they have never won in the Premier League.In 11 visits to City’s home ground, Sunderland have lost nine and drawn two. They last won at City in January 1998 in the second tier.And Sunderland have picked up just five points in their last 11 Premier League away games, winning one, drawing two and losing eight. The Black Cats have also conceded the most goals (33) and have allowed their opponents the most shots on target (106) in the Premier League this season.City recalled Sergio Aguero for the Arsenal game though, after three games out, he lasted just over an hour before being replaced. City were still without Vincent Komapny but the captain could return in time to face Sunderland.Fernando and Pablo Zabaleta also missed the Emirates match and will undergo tests. But Samir Nasri is still absent.Sunderland, meanwhile, will miss Jack Rodwell after the midfielder collected his fifth yellow card of the season, at Chelsea. Sebastian Larsson is also missing while Lee Cattermole a doubt after missing the last game with a back problem.